Biochemical EngIneering

Course Coordinator

ECTS points:


Course number:

Course Description


  1. Definition, importance and range of biochemical engineering and its development directions
  2. Bioreactor systems for biotechnological production
  3. Bioprocess conduction manners – batch and fed batch process
  4. Bioprocess conduction manners – semi-continuous and continuous process
  5. Mixing and aeration in bioprocesses
  6. Monitoring, control and regulation of bioprocesses
  7. Sterilisation of equipment, media and air for biotechnological production
  8. Application of mathematical models in biotechnological production
  9. Immobilised biocatalytic systems
  10. Separation and purification of biotechnological products


  • prepare cultivation media and inoculum for different bioprocess conduction manners (batch, fed batch, semi-continuous and continuous)
  • establish and solve mass balance and quantify bioprocess kinetics for different bioprocess conduction manners
  • establish and manage different bioprocess conduction manners
  • calculate bioprocess efficiency parameters for different bioprocess conduction manners
  • propose adequate equipment for bioprocess conduction on semi-solid and solid substrate as well as on liquid cultivation media
  • create and build up optimal system for monitoring and control of bioprocesses
  • calculate, establish and manage of batch and continuous sterilization of cultivation media as well as air sterilization
  • develop and use mathematical models for bioprocess control and optimization
  • propose and create systems for bioprocess conduction with immobilized biocatalysts of first and second generation
  • propose adequate process for microbial biomass separation, microbial cells disruption and separation of microbial metabolism products
  • create and build up optimal technological line for bioprocess conduction in industrial scale

To enrol in this course, the following courses must be completed:

  • Transport Phenomena
  • Unit Operations
  • Biotechnology 2
  • Biochemistry 1
  • Biochemistry 2
  • Microbiology
  • Numerical Methods and Programming
  • Matemathics 2
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