Course Coordinator

ECTS points:


Course Description

Genotoxic agents. Professional and occupational exposure. Mutagen/carcinogen interactions with cellular macromolecules. Biotransformation. Biological test systems used for genotoxicity determination. Genotoxic compounds in water, air and soil. Molecular biology techniques in environment protection. Horizontal gene transfer. Alteration in embryonic development of invertebrates as ecotoxicity tests. Multixenobiotic resistance system.

Learning outcomes

  • list and describe genotoxic agents and their mechanisms of action
  • identify links and synergy effects of various xenobiotics on genome
  • predict the possible risks of use of genotoxic substances
  • specify and describe ecotoxicological tests and methods
  • apply the principle and knowledge in order to reduce emissions of toxic substances


Types of Teaching:   Sati
Lectures 10
Seminars 2
Laboratory practices  




1. Chemical consequences: environmental mutagens, scientist activism and the rise of genetic toxicology. Frickel, Scott (2004), ed. Frickel Scott, Rutgers University Press, Book News Inc, Portland, OR USA
2. Genetic and toxicology. Forbes, E. Valery (1998), ed. Forbes E. Valery, CRC Press, NY, USA
3. Basic toxicology. Lu, C. Frank (1991), ed. A.N. Bartlett, Hemisphere publishing corporation, Bristol, PA, USA
4. Tamaris RH. Principes of genetics; WCB/McGraw-Hill, six edition, 1999.