Signal transduction in cells

ECTS points:
3

Program:
doktorski

Course Description

Cell to cell communication is obligatory for the survival of all organisms. It is responsible for the basic cell processes such as differentiation, proliferation, growth and death. These events engage a variety of signaling molecules that bind to cell-surface or intracellular receptors thus inducing a specific cellular responses. In depth understanding of the basic cell signaling pathways is key factor for the drug development of already existed therapeutics (e. g. Herceptin, Gleevec) as well as for the discovery of potential new drugs.

On successful completion of this module, students will be able to:

  • define the major signaling molecules and signal transduction pathways in cells
  • describe the role of signaling pathways in different physiological processes
  • illustrate approaches of drug development based on acquired knowledge on cell signaling pathways
  • demonstrate critical thinking in the field of drug development based on case study analysis from appropriate references 

Lectures

Lectures: 15 h

Seminars: 7,5 h

Examination: Seminar and oral exam

Literature

De Cuyper, M., Bulte, J.W.F. (2001) Physics and Chemistry Basis of Biotechnology, Kluwer Academic Publishers, Dordrecht, Nizozemska

Van Broekhoven, A., Shapiro, F. (2001) Novel Frontiers in the Production of Compounds for Biomedical Use, Kluwer Academic Publishers, Dordrecht, Nizozemska

Willars G.B., Challiss R.A. (2004) Receptor signal transduction protocols, Humana Press, Totowa, USA

Dickson R.C., Mendenhall M.D. (2004) Signal transduction protocols, Humana Press, Totowa, USA