Associate |
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COURSE CONTENT
Lectures: Metabolism: basic concepts, ATP as energy transporter in biological systems. Glycolysis: reactions, energy yield, mechanisms of glycolysis regulation. Fate of pyruvate under anaerobic conditions. Production of acetyl-CoA from pyruvate: the pyruvate dehydrogenase complex; reaction mechanism and regulation. The citric acid cycle: reactions, energy yield and regulation. The glyoxylate cycle. Oxidative phosphorylation. Gluconeogenesis. Photosynthesis. Pentose phosphate pathway. Glycogen metabolism: signal transduction pathways and mechanism of reciprocal regulation of glycogen breakdown and synthesis. Fatty acid metabolism. Amino acid metabolism. Urea cycle. The control of gene expression. Biological membranes and transport. Integration of metabolic pathways
Seminars: Solving of selected problems on: bioenergetics, energy yield calculation for basic catabolic and anabolic processes, regulation of metabolic pathways.
LEARNING OUTCOMES
To enrol in this course, the following courses must be completed:
1. J.M. Berg, J.L. Tymoczko, L. Stryer, Biokemija, Školska knjiga, Zagreb, 2013.
2. J.M. Berg, J.L. Tymoczko, G.J. Gatto, L. Stryer, Biochemistry (eighth edition), W.H. Freeman and Co., New York, 2015.
3. D.L. Nelson, M.M. Cox, Lehninger Principles of Biochemistry (third edition), Worth Publisher, New York, 2000.
4. M. Osgood, K. Ocorr, The Absolute, Ultimate Guide to Lehninger Principles of Biochemistry (third edition) , Worth Publisher, New York, 2000.