Lipase-catalysed preparation of chiral compounds

Course Description

Biocatalytic transformations found very wide application for preparation of chiral compounds because they possess high regio - and stereoselectivity. Activities of enzymes in organic solvents open a new area in bioorganic chemistry. Microbial and fungal lipases which exhibit high selectivity towards a broad range of substrates and very good stereoselectivity belong to the most available enzymes for various types of transformations. Enantioselective synthesis of alcohols, diols, poliols and amines, synthesis of amides and peptides, transesterifications of lipides, diastereoselective esterifications or hydrolysis, acylation and deacylation under the mild reaction conditions occured in such transformations with high stereoselectivity. The optically pure compounds obtained are used as chiral sintons in synthesis of bioactive or important industrial compounds used in pharmacy, biotechnology, food industry and agriculture.

Aim of course:

The course includes fundamental knowledge about biocatalytic preparation of chiral compounds which are important for the title studies.

Lectures

Lectures: 10

Seminars: 10

Literature

1. M. Nógrádi, Stereochemistry, Akadémiai Kiadó, Budapest, 1981.
2. L. Poppe, L Novák, Selective Biocatalysis, Wiley-VCH, Weinheim, New York, Cambridge, Basel, 1992.
3. K. Faber, Biotransformations in Organic Chemistry, Springer-VerlagBerlinHeidelbergNew York, 1997.
4. K. Drauz, H. Waldmann, Enzyme Catalysis in Organic Synthesis, Wiley-VCH, Weinheim, New York, Cambridge, Tokyo, 1995.
5. U. T. Bornscheuer, R. J. Kazalauskas, Hydrolases in Organic Synthesis, Wiley-VCH, Weinheim, New York, Chichester, Brisbone, Singapore, Toronto, 1999.