Peptidomimetics and Pseudopeptides

Course Coordinator

Associate

ECTS points:
3

Program:
diplomski

Course number:
53304

Course Description

COURSE CONTENT

  • Natural peptides: the role and structure.
  • Mimetics of alpha-helix.
  • Mimetics of turn.
  • Mimetics of beta-sheet.
  • Ferrocene peptidomimetics.
  • Carbohydrate peptidomimetics. Petidomimetics as artificial sweeteners.
  • Structure and function of natural peptide mimetics (hormones, N-acetylglucosamine, apolipoproteins, etc)
  • Conformational analysis in solution by using the spectroscopic techniques (IR, NMR and CD spectroscopy).

LEARNING OUTCOMES

  • analyse and argue how to overcome the disadvantages of the natural peptides (proteolytic instability, polarity, conformational freedom) by using adequately designed mimetics
  • analyse and identify peptide and non-peptide structures that mimic the secondary structural element (helix, sheet or turn) involved in molecular recognition
  • design and synthesis of ferrocene peptides as potential mimetics of peptide secondary structural elements
  • perform the conformational analysis of ferrocene peptidomimetics in solution by using standard spectroscopic techniques (IR, NMR and CD) with the aim to define their secondary structure
  • predict and evaluate the potential pharmacological and biotechnological application of peptidomimetics.

Teaching materials [2]

Naziv datoteke Veličina Ubačeno/mijenjano  
Broj preuzimanja: 160  Peptidni mimetici i pseudopeptidi - interna skripta 2.71 MB 19/06/2018 11:43 am
Broj preuzimanja: 3  Predavanja 11.17 MB 10/01/2019 2:21 pm

Notice [3]

Naziv datoteke Veličina Ubačeno/mijenjano  
Broj preuzimanja: 407  Upis kolegija 21.98 kB 22/10/2013 11:22 am
Broj preuzimanja: 432  Ishodi ucenja 22.24 kB 11/02/2015 9:16 am
Broj preuzimanja: 264  Obavijest o početku nastave 58.46 kB 23/09/2015 1:42 pm