The fundamentals of bioorganometallic chemistry

Course Coordinator


Course Description

Course module title

The fundamentals of bioorganometallic chemistry

Course content




1. Definition and historical background of bioorganometallic chemistry, overview of
previous development. / 2 hours


2. Naturally-ocurring bioorganometallic. / 2 hours


3. Organometallic targeted to specific biological sites: the development of new
therapies. / 2 hour


4. Conjugates of peptides and PNA with organometallic complexes. Genosensors. / 3


5. Organometallic bioprobes. / 2 hours


6. Organometallic complexes as tracers in non-isotopic immunoassay. / 2 hours


7. Supramolecular host recognition processes with biological compounds. Structure and
mechanism of metalloenzyme active site. / 2 hours


Laboratory practice exercises


1. Coupling of ferrocene amino acid with natural amino acids by using HOBt/ EDC method. / 4 hours


2. Synthesis of ferrocene conjugates with carbohydrate amino acid. / 4 hours


3. Isolation of prepared bioconjugates from reaction mixture. TLC-purification. / 8

4. IR and NMR characterization of prepared bioconjugates. / 7 hours

Teaching practices and methods

Lectures and laboratory practice exercices

Evaluation of student learning

Oral report - presentation

Notice [0]

Naziv datoteke Veličina Ubačeno/mijenjano  

Teaching materials [0]

Naziv datoteke Veličina Ubačeno/mijenjano  


Literature list


1. G. Jaouen (Editor), Bioorganometallics: Biomolecules, Labeling, Medicine, John Wiley
& Sons, Weinheim, 2006.


2. G. Simonneaux (Editor), Bioorganometallic Chemistry (Topics in Organometallic
Chemistry), Springer-Verlag Berlin Heidelberg, 2006.

3. D. R. van Staveren, N. Metzler-Nolte, Bioorganometallic Chemistry of Ferrocene,
Chem. Rev. 104 (2004) 5931-5985.