The fundamentals of bioorganometallic chemistry

Course Coordinator

Program:
diplomski

Course Description

Course module title

The fundamentals of bioorganometallic chemistry

Course content

 

Lectures

 

1. Definition and historical background of bioorganometallic chemistry, overview of
previous development. / 2 hours

 

2. Naturally-ocurring bioorganometallic. / 2 hours

 

3. Organometallic targeted to specific biological sites: the development of new
therapies. / 2 hour

 

4. Conjugates of peptides and PNA with organometallic complexes. Genosensors. / 3
hours

 

5. Organometallic bioprobes. / 2 hours

 

6. Organometallic complexes as tracers in non-isotopic immunoassay. / 2 hours

 

7. Supramolecular host recognition processes with biological compounds. Structure and
mechanism of metalloenzyme active site. / 2 hours

 

Laboratory practice exercises

 

1. Coupling of ferrocene amino acid with natural amino acids by using HOBt/ EDC method. / 4 hours

 

2. Synthesis of ferrocene conjugates with carbohydrate amino acid. / 4 hours

 

3. Isolation of prepared bioconjugates from reaction mixture. TLC-purification. / 8
hours

4. IR and NMR characterization of prepared bioconjugates. / 7 hours

Teaching practices and methods

Lectures and laboratory practice exercices

Evaluation of student learning

Oral report - presentation

Notice [0]

Naziv datoteke Veličina Ubačeno/mijenjano  

Teaching materials [0]

Naziv datoteke Veličina Ubačeno/mijenjano  

Literature

Literature list

 

1. G. Jaouen (Editor), Bioorganometallics: Biomolecules, Labeling, Medicine, John Wiley
& Sons, Weinheim, 2006.

 

2. G. Simonneaux (Editor), Bioorganometallic Chemistry (Topics in Organometallic
Chemistry), Springer-Verlag Berlin Heidelberg, 2006.

3. D. R. van Staveren, N. Metzler-Nolte, Bioorganometallic Chemistry of Ferrocene,
Chem. Rev. 104 (2004) 5931-5985.