Peptidomimetics and Pseudopeptides
Course Coordinator |
Associate |
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Course Description
COURSE CONTENT
- Natural peptides: the role and structure.
- Mimetics of alpha-helix.
- Mimetics of turn.
- Mimetics of beta-sheet.
- Ferrocene peptidomimetics.
- Carbohydrate peptidomimetics. Petidomimetics as artificial sweeteners.
- Structure and function of natural peptide mimetics (hormones, N-acetylglucosamine, apolipoproteins, etc)
- Conformational analysis in solution by using the spectroscopic techniques (IR, NMR and CD spectroscopy).
LEARNING OUTCOMES
- analyse and argue how to overcome the disadvantages of the natural peptides (proteolytic instability, polarity, conformational freedom) by using adequately designed mimetics
- analyse and identify peptide and non-peptide structures that mimic the secondary structural element (helix, sheet or turn) involved in molecular recognition
- design and synthesis of ferrocene peptides as potential mimetics of peptide secondary structural elements
- perform the conformational analysis of ferrocene peptidomimetics in solution by using standard spectroscopic techniques (IR, NMR and CD) with the aim to define their secondary structure
- predict and evaluate the potential pharmacological and biotechnological application of peptidomimetics.
Teaching materials [2]
| Naziv datoteke | Veličina | Ubačeno/mijenjano | |
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Peptidni mimetici i pseudopeptidi - interna skripta
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2.71 MB | 02/09/2022 5:05 pm | |
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Predavanja
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14.78 MB | 29/09/2023 7:25 pm |
Notice [3]
| Naziv datoteke | Veličina | Ubačeno/mijenjano | |
|---|---|---|---|
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Upis kolegija
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21.98 kB | 02/09/2022 5:05 pm | |
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Ishodi ucenja
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22.24 kB | 02/09/2022 5:05 pm | |
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Obavijest o početku nastave
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58.46 kB | 02/09/2022 5:05 pm |