Lipase-Catalysed Preparation of Chiral Compounds

Course Coordinator

ECTS points:
3

Program:
diplomski

Course number:
53303

Course Description

COURSE CONTENT

  • Introductory overview of basic concepts in the field of stereochemistry
  • Methods of separation of racemates
  • Lipase (microbes and fungal)
  • Application of optically pure compounds in stereoselective synthesis
  • Chiral syntones in the synthesis of biologically active or industrially important compounds
  • Calculation of enantiomeric and diastereomeric excess.
  • Determination of parameters of efficiency chiral columns for HPLC and GC
  • Preparation of optically pure alcohols and diols from prochiral or meso or racemic starting compounds
  • Preparation of optically active polyhydroxy compounds.

LEARNING OUTCOMES

  • distinguish and list the terms of stereochemistry (stereoselectivity, stereospecificity, kinetic resolution, etc.)
  • describe and analyze the enzyme / lipase selectivity of the substrate
  • select and compare biotransformation reactions under different conditions
  • perform stereoselective reactions, and argue and summarize the obtained results
  • adapt and solve the set requirements for the synthesis of chiral compounds