Lipase-Catalysed Preparation of Chiral Compounds
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Course Description
COURSE CONTENT
- Introductory overview of basic concepts in the field of stereochemistry
- Methods of separation of racemates
- Lipase (microbes and fungal)
- Application of optically pure compounds in stereoselective synthesis
- Chiral syntones in the synthesis of biologically active or industrially important compounds
- Calculation of enantiomeric and diastereomeric excess.
- Determination of parameters of efficiency chiral columns for HPLC and GC
- Preparation of optically pure alcohols and diols from prochiral or meso or racemic starting compounds
- Preparation of optically active polyhydroxy compounds.
LEARNING OUTCOMES
- distinguish and list the terms of stereochemistry (stereoselectivity, stereospecificity, kinetic resolution, etc.)
- describe and analyze the enzyme / lipase selectivity of the substrate
- select and compare biotransformation reactions under different conditions
- perform stereoselective reactions, and argue and summarize the obtained results
- adapt and solve the set requirements for the synthesis of chiral compounds