Toxicology (Graduate Study of Molecular Biotechnology )

Course Coordinator

ECTS points:
3

Program:
diplomski

Course number:
53252

Course Description

COURSE CONTENT

  • The history of toxicology and the role of toxology as a science
  • Classifications of toxic substances. The basic toxicological terms.
  • Quantitative aspects of toxicity
  • In vivo and in vitro toxicity tests
  • ADME (Absorption, Distribution, Metabolism and Excretion) of a toxicant (basics). Accumulation of toxic compounds in the body
  • Biotransformation of xenobiotics - basics
  • Target sites of xenobiotic activity. Toxicodynamics
  • Pesticides - residues in food and toxic effects. Impact of processing on pesticide residues in food
  • Heavy metals -  residues in food and toxic effects. Impact of processing on metal content in food
  • Thermally induced toxicants in food

LEARNING OUTCOMES

  • define and explain basic terms and principles in toxicology
  • classify toxicants and explain toxicokinetics and toxicodynamics processes (basics)
  • explain quantitative aspects of toxicity (basics) and effects of toxic substances at the molecular and cellular level
  • classify toxicants that may be formed during food processing and explain mechanisms of their toxic action
  • describe animal and alternative toxicity tests, as well as biological, physical and chemical methods for determination of toxicants in food
  • apply alternative toxicity tests and quantify toxic effects of xenobiotics
  • explain, compile and evaluate inputs for environmental risk assessment and analyze possibility of adverse effects outcomes