Toxicology (Graduate Study of Molecular Biotechnology )

Course Description

COURSE CONTENT

• The history of toxicology and the role of toxology as a science
• Classifications of toxic substances. The basic toxicological terms.
• Quantitative aspects of toxicity
• In vivo and in vitro toxicity tests
• ADME (Absorption, Distribution, Metabolism and Excretion) of a toxicant (basics). Accumulation of toxic compounds in the body
• Biotransformation of xenobiotics - basics
• Target sites of xenobiotic activity. Toxicodynamics
• Pesticides - residues in food and toxic effects. Impact of processing on pesticide residues in food
• Heavy metals -  residues in food and toxic effects. Impact of processing on metal content in food
• Thermally induced toxicants in food

LEARNING OUTCOMES

• define and explain basic terms and principles in toxicology
• classify toxicants and explain toxicokinetics and toxicodynamics processes (basics)
• explain quantitative aspects of toxicity (basics) and effects of toxic substances at the molecular and cellular level
• classify toxicants that may be formed during food processing and explain mechanisms of their toxic action
• describe animal and alternative toxicity tests, as well as biological, physical and chemical methods for determination of toxicants in food
• apply alternative toxicity tests and quantify toxic effects of xenobiotics
• explain, compile and evaluate inputs for environmental risk assessment and analyze possibility of adverse effects outcomes